Triamterene EP Impurity A
5-Nitroso-2,4,6-triaminopyrimidine
CAS: 1006-23-1
Molecular Formula: C4H6N6O
Triamterene EP Impurity A - Names and Identifiers
| Name | 5-Nitroso-2,4,6-triaminopyrimidine |
| Synonyms | IFLAB-BB F1918-0051 Triamterene EP Impurity A 6-pyrimidinetriamine,5-nitroso-4 5-nitropyrimidine-2,4,6-triamine 2,4,6-Triamino-5-nitrosopyrimidine 2,4,6-TRIAMINO-5-NITROSOPYRIMIDINE 5-nitrosopyrimidine-2,4,6-triamine 5-NITROSO-2,4,6-TRIAMINOPYRIMIDINE 5-Nitroso-2,4,6-triaminopyrimidine 2,4,6-Triamino-5-nitroisopyrimidine 5-NITROSO-PYRIMIDINE-2,4,6-TRIAMINE |
| CAS | 1006-23-1 |
| EINECS | 213-742-7 |
| InChI | InChI=1/C4H6N6O2/c5-2-1(10(11)12)3(6)9-4(7)8-2/h(H6,5,6,7,8,9) |
| InChIKey | XLQQJSWJHHKLOK-UHFFFAOYSA-N |
Triamterene EP Impurity A - Physico-chemical Properties
| Molecular Formula | C4H6N6O |
| Molar Mass | 154.13 |
| Density | 1.4788 (rough estimate) |
| Melting Point | 300 °C |
| Boling Point | 277.47°C (rough estimate) |
| Flash Point | 326.9°C |
| Solubility | DMF (Slightly, Heated), DMSO (Slightly, Heated) |
| Vapor Presure | 3.78E-15mmHg at 25°C |
| Appearance | neat |
| Color | Light Pink to Pink |
| pKa | 4.07±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.7290 (estimate) |
| MDL | MFCD00006096 |
| Physical and Chemical Properties | Appearance: Red Crystal Melting Point:>300 ℃ |
| Use | Used as a pharmaceutical Intermediate |
Triamterene EP Impurity A - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29335990 |
Triamterene EP Impurity A - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Application | 5-nitroso -2,4, 6-triaminopyrimidine is a pyrimidine derivative, which can be used as an intermediate in organic synthesis. |
| Preparation | 5-nitroso -2,4, 6-triaminopyrimidine can be prepared by reacting 6-aminopyrimidin-2, 4-diamine with NaNO2. |
| use | as an intermediate of the drug azopteridine and azopterin. Used as a pharmaceutical intermediate |
| Production method | It is obtained by nitrosation of 2,4, 6-triaminopyrimidine. Put 2,4, 6-triaminopyrimidine and sodium nitrite into ice water, add hydrochloric acid dropwise below 10 ℃, keep pH = 4.5-4.8, and react below 20 ℃ for 1h. Filtration, washing and drying to obtain 5-nitroso-2, 6-triaminopyrimidine with a yield of more than 50%. |
Last Update：2024-04-10 22:29:15
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